First-of-its-kind technology advances the ability to detect and analyze exosomes with high sensitivity and specificity
BOSTON, MA — February 4, 2019 — NanoView Biosciences, Inc. today launched its first product, the ExoView™ platform, to enable the accurate identification and characterization of exosomes. The platform is on display this week at the SLAS2019 International Conference & Exhibition in Washington, DC.
Exosomes are a type of extracellular vesicle, tiny particles released by cells as a means of communicating with other cells. The nucleic acids, lipids, and proteins carried by exosomes make them highly promising for diagnostic, prognostic, and even therapeutic use for a broad range of diseases including cancer. To date, no commercial technology has been capable of detecting and confirming exosome biomarkers with high specificity and sensitivity.
Like circulating tumor cells and cell-free DNA, which are now commonly analyzed via liquid biopsies for cancer and other diseases, exosomes have the advantage of being easily accessible through samples such as blood, urine, and saliva. However, exosomes are difficult to isolate and detect with conventional technologies because these particles are up to 1 million times smaller than cells; cellular analysis platforms such as flow cytometry typically do not provide sufficient sensitivity; and other nanoparticle detection technologies do not deliver the specificity to differentiate between biologically relevant exosomes and other small particles or contaminants.
“There is tremendous excitement in the scientific and clinical research communities around exosomes, which are already believed to be important for cardiology, regenerative medicine, neurodegenerative diseases, and cancer,” said Jerry Williamson, CEO of NanoView Biosciences. “With the ExoView platform, for the first time scientists can fully characterize exosomes and validate their molecular cargo as biomarkers for disease. We believe this will be instrumental in ushering exosomes into routine clinical use for noninvasive testing and more personalized patient care.”
The ExoView platform is the first commercially available product able to provide high-resolution sizing, counting, and phenotyping of exosomes at the individual vesicle level. The platform can measure the size of single exosomes as small as 50 nm and determine the concentration of exosomes expressing specific surface or molecular markers with excellent sensitivity.1 This microarray-based technology enables label-free detection and sizing of exosomes with no purification required, no sample prep and minimal hands-on time. Captured exosomes can be phenotyped for surface and internal biomarkers. The ExoView platform can be used directly on complex biological samples and requires very little sample input.
“This platform will be transformative in its ability to enhance our understanding of exosomes and their biological importance,” said George Daaboul, Chief Scientific Officer of NanoView Biosciences. “By offering a higher-resolution view of exosomes and extracellular vesicles than has ever been possible, we believe the ExoView technology will ultimately enable future life science breakthroughs based on the use of extracellular vesicles in research and the clinic.”
SLAS attendees can learn more about the ExoView system by visiting NanoView Biosciences in booth 348 and viewing posters 1307-C and 1344-E. See details below:
Poster Title: Interferometric Imaging for High-Throughput Single Exosome and Extracellular Vesicle Characterization
Poster Presentation Date: Tuesday February 5, 2019
Poster Presentation Time: 2:00 PM - 3:00 PM
Poster Number: 1307-C
Poster Title: Tumor Derived Exosomes and Extracellular Vesicles from Plasma Characterized using Interferometric Imaging
Poster Presentation Date: Wednesday February 6, 2019
Poster Presentation Time: 11:30 AM - 12:30 PM
Poster Number: 1344-E.
The ExoView platform is designed For Research Use Only. It is not for use in diagnostic procedures.
Reference
1. Daaboul et al. “Digital Detection of Exosomes by Interferometric Imaging.” Scientific Reports, 2016.
About NanoView Biosciences
NanoView Biosciences, a Boston-based, privately-held company, is focused on enabling life science researchers to better understand the biological role of exosomes and their potential use as biomarkers for improving the diagnosis, prognosis, treatment, and monitoring of disease. The company’s proprietary product, the ExoView™ system, was designed to fully characterize exosomes and other extracellular vesicles for use in research and translation into precision medicine products. ExoView is a high-throughput, cost-effective analysis platform that is easy to use and does not require purification or large sample volumes to accurately analyze exosomes.
